Prescribing Information | Important Safety Information
Prescribing Information | Important Safety Information

Privacy Policy

If you have contacted us, your e-mail address will be stored on our server but will not be used for commercial purposes unless you have granted permission for that.

Terms of Use:


SWEDISH ORPHAN BIOVITRUM AB (PUBL) developed this Web site as a service. The information and literature on this Web site is provided for general information only. Medical information that appears on this Web site is for informational purposes only and is not a replacement for advice given by a physician or other medical professionals. While SWEDISH ORPHAN BIOVITRUM AB (PUBL) makes reasonable efforts to ensure the timeliness and accuracy of the materials present on this Web site, it makes no assurances or warranties (express or implied) as to the accuracy of the information provided on this Web site and shall not be liable for any direct, indirect, incidental, consequential or otherwise special damages or injuries resulting from the use of this Web site and reliance on the materials contained here. SWEDISH ORPHAN BIOVITRUM AB (PUBL) may make changes to these materials at any time, without notice, and makes no commitment to update the information contained herein.


This Web site may contain links to other completely independent Internet pages maintained by third parties over whom SWEDISH ORPHAN BIOVITRUM AB (PUBL) has no control. SWEDISH ORPHAN BIOVITRUM AB (PUBL) does not have any responsibility for ensuring that such pages are correct and updated. SWEDISH ORPHAN BIOVITRUM AB (PUBL) has absolutely no liability in regard to the content of other Web sites, and provides links solely as a service to our visitors. Linking and visits to other Web sites via SWEDISH ORPHAN BIOVITRUM AB (PUBL)’s Web site is thus completely at your own risk.


All content on this Web site is protected by copyright. You may only use the information in the text, photos, graphs etc. for your own non-commercial use and it is not permitted to reproduce, modify, transfer, license or publish anything from this Web site, in its entirety or in part, without the written permission of SWEDISH ORPHAN BIOVITRUM AB (PUBL) in advance.


All trademarks, logotypes and layout objects on the Web site are the property of SWEDISH ORPHAN BIOVITRUM AB (PUBL), or belong to a third party. It is prohibited to use, download, copy or distribute these in any form without the written consent of SWEDISH ORPHAN BIOVITRUM AB (PUBL), or where relevant from a third party.


This Web site uses cookies, small pieces of information stored in the memory of the browser of any user of this site, to enable us to collect information about that user's use of it. Please be assured that we DO NOT collect or seek through these tags or cookies any personally identifiable information about our visitors, such as names, addresses, e-mail addresses, or telephone numbers.

Privacy information

If you have contacted us, your e-mail address will be stored on our server but will not be used for commercial purposes unless you have granted permission for that.

Questions? Call Us.

Indication and Usage

Orfadin is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase indicated for use as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1 (HT-1).

Important Safety Information

    • Tyrosine levels can increase in the blood if you do not restrict tyrosine and phenylalanine in your diet while taking Orfadin. Too much tyrosine in the blood can cause serious eye problems or other complications.
    • Do not adjust your Orfadin dosage in order to lower the tyrosine levels in the blood.
    • A reduction in the number of white cells and platelets in the blood have been observed during treatment with Orfadin. Your platelet and white blood cell counts should be monitored regularly during Orfadin treatment.
    • The most common adverse reactions to taking Orfadin are liver cancer, liver failure, low platelets or white cells in the blood, and complaints related to the eyes, including conjunctivitis, corneal opacity, inflammation of the cornea, and extreme sensitivity to light.
    • Tell your physician promptly if you have unexplained eye symptoms, rash, jaundice (yellowing of the skin or whites of the eyes) or excessive bleeding.
    • Use Orfadin during pregnancy only if the potential benefit justifies the potential risk to the fetus.
    • Nursing women should discontinue either Orfadin or breast-feeding based on the recommendation of your healthcare professional.
      Please see full Prescribing Information